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[11] [12] The combination might theoretically offer complementary cardiovascular support, but robust evidence is lacking, and neither is included in UK clinical guidelines for cardiovascular disease management or lipid modification

MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]

Half-life is 7 to 34 hours and is, in part, dependent on urine pH (half-life is longer with alkaline urine)

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