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It found that IV and oral administration of Fragment 176-191, when compared to placebo, led to no changes in: physical findings, laboratory parameters, glucose levels, glucose tolerance, insulin sensitivity, IGF-1 levels, or rates of adverse events (e.g

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Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficientparticularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required