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Additionally, conditions such as pernicious anemia, gastrointestinal disorders, or even aging can impair B12 absorption

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More specifically, it causes the active forms to convert to cyanocobalamin, causing a functional deficiency

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Stress and illness often involve systemic inflammation that damages follicles

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However, the long-term systemic effects of chronic NNMT inhibition on methylation pathways, liver function, and cardiovascular health have not been studied

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