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validation, T.C.O., R.S., N.F.R

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Spataro, 1984

AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB

Acetaminophen causes its harmful effects on the liver mainly through N-acetyl-p-benzoquinoneimine, an extremely toxic metabolite formed by cytochrome CYP 2E1 and CYP 1A2 enzymes