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The evidence base consists primarily of preclinical studies in animal models, with limited clinical data in humans

major inhibited the proliferation of susceptible (A2780) and resistant (A2780-CP) ovarian cancer cell lines to cisplatin due to their complex excretion/secretion antigens [302]

At its core, glutathione is just three amino acids - cysteine, glycine, and glutamic acid linked together

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Free radicals in biological materials

Key roles of glutathione include: Antioxidant defense neutralizes reactive oxygen species that damage DNA, proteins, and cell membranes, as documented in research on the Past and Present of antioxidant studies spanning multiple decades Detoxification binds to heavy metals, pollutants, and drug metabolites so they can be excreted in urine or bile Immune balance supports T cells and other immune cells that respond to infections and inflammation Mitochondrial protection guards the energy-producing machinery in cells from oxidative damage Cell repair and turnover influences cell growth and programmed cell death ( apoptosis ) Glutathione levels tend to decline with: Age Chronic stress and poor sleep Environmental toxin exposure Chronic illness and ongoing inflammation That decline is linked to neurodegenerative conditions, immune dysregulation, and respiratory disease, which is why so many people look for effective ways to support glutathione