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[165 166] The International Society of Lymphology defines lymphedema as an external (and/or internal) manifestation of lymphatic system insufficiency and deranged lymph transport and is a symptom or sign resulting from underlying lymphatic disease. [167] The Centers for Disease Control and Prevention (CDC) defines lymphedema as swelling due to a buildup of lymph fluid in the body

These findings indicate that BPC 157 exerts its pro-angiogenic effects by increasing VEGFR2 expression and promoting its internalization and subsequent activation of the VEGFR2-Akt-eNOS signaling cascade