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doi: 10.1038/nm.3624 101 RobbaC.BattagliniD.BallL.PatronitiN.LoconteM.BrunettiI.et al

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The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-kappaB signaling

This can be done for various reasons, including to improve the appearance of scars, hyperpigmentation, or other skin blemishes or to even out the skin tone

doi: 10.1093/jn/131.9.2535S 26 NewsholmeP

In simple terms, the sequence can be viewed as: Because the first reactions happen right at the leaf surface and apoplast, the strength of the apoplastic antioxidant shield is a key deciding factor
