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Their implication in xenobiotic detoxification, such as herbicides, has likely little to do with their ancestral functions, that still remain to be delineated in many cases

99 Resveratrol increased the enzyme activity like catalase, SOD, heme oxygenase, and glutathione peroxidase while inhibiting xanthine oxidase

Acknowledgements We thank Karin Schlegelmilch for constructive discussions and advice on YAP1, Steve Hooper for cloning and Erik Sahai for providing the pBabe YAP1 5SA-YFP plasmid, all members of the Department of Translational Genomics for constructive feedback, Henning Walczak and Manolis Pasparakis for providing recombinant TRAIL and TNF, respectively, Johannes Khle for providing buffy coats and Trudy Oliver for advice

The functional conservation of both GSTs and SULTs across species highlights their evolutionary significance in cellular detoxification and stress regulation, which are essential for maintaining homeostasis and preventing cellular damage 52

coli bacterial -glucuronidase inhibitor, exhibiting an IC and a 50 K of 283 nM and 164 nM, respectively