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It is interesting to note that when combined with conventional chemotherapy drugs such as doxorubicin, cyclophosphamide, and taxanes, these fatty acids improve cancer cells sensitivity to cytotoxic drugs, lessen side effects like cachexia, neuropathy, or myelosuppression, or overcome multidrug resistance (168)

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Setmelanotide, both alone and in combination, also demonstrated a significant increase in energy expenditure compared to liraglutide alone