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In PIONEERI and PIONEERII clinical trials for Adalimumab, 41.8% and 58.9% of HS patients reached, respectively, a HiSCR (Hidradenitis Suppurativa Clinical Response), defined as a 50% reduction in the total abscess and inflammatory nodule (AN) count [226]

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However, due to lifestyle factors such as limited sun exposure and dietary insufficiencies, many individuals experience Vitamin D deficiency, which can manifest as fatigue, depression, and weakened immune response