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Another study further demonstrated that the FAD/NAD(P)H-binding site of FSP1 is evolutionarily conserved among NADH quinone reductases, and targeting this region enabled the development of viFSP1, a species-independent inhibitor that interacts with the NAD(P)H-binding pocket of FSP1 121

Pathway enrichment analyses of the upregulated genes against MSigDB Hallmark 2020 database were performed via Enrichr

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Thus, we postulate that pyridoxine is a relatively safe candidate for PD therapy

[PubMed 9035553] 2156

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