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You should always take it as it has been prescribed for you

References: Misra M

"The Relation of Cytotoxin-Associated Gene A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori-Positive Patients"

However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future