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Journal of Neuroscience Research, 91(10), 1296-1305

doi: 10.1159/000471813

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In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)

Other stressors such as emotional stress or dehydration also disrupt healthy circulation causing dark circles under the eyes

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