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Zhang L, Zhu L, Tang L, Xie J, Gao Y, Yu C, Shang K, Han H, Liu C, Lu Y

Aust Fam Physician

ROS activates NF-B by inhibiting the phosphorylation of IB

Consequently, the timing, concentration and dosage of antioxidants, along with their bioavailability and effective targeted delivery to specific organs, are important factors that are often challenging to regulate in clinical practice

81 In parallel, the expression of ATP-binding cassette (ABC) transporters, especially P-gp (ABCB1), MRP1 (ABCC1) and BCRP (ABCG2), expressed both on tumour cells and in the BBB, as drug efflux pumps has been proven to play a crucial role in multidrug-resistance

The primary safety advantage is the lack of IGF-1 elevation