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It is important to highlight that the COVID-19 patients were enrolled in the mild group based on their lower oxygen requirement (nasal cannula 4 l or less or no oxygen), which differs from other studies where only outpatients displaying no oxygen requirement were assigned as mild patients

PAC1R, VPAC1R, and VPAC2R) have been identified, and they can activate diverse pathways, including the signaling through AC (169)

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HK is a key rate-limiting enzyme in the first step of glycolysis in tumor tissues, and its expression and activity increase in tumor tissues to promote effective anaerobic glycolysis even under anaerobic conditions (7)

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