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In in vivo tests, the PMP-PI group showed better therapeutic outcomes than the PMP-P group, as indicated by healthier lung tissue appearance, reduced hemorrhage, lower lung weight, and less edema ( Figure 3M )

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For the comparison between the fatal and survival patients, the concentration of SM 18:0 was significantly lower, while TAG 56:5-FA22:4 was significantly higher ( Figures 4H, I )