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On the Evidence The existing in vitro and organ culture data is promising and mechanistically coherent, but the compound has not undergone large-scale randomised controlled trials

However, comprehensive long-term human safety data does not exist

and is useful in some cases of allergies by virtue of its ability to reduce histamine release.123 One of the sulfur-containing amino acids (along with cysteine and cystine), methionine is important (essential) to many bodily functions and must be directly consumed through supplementation or methionine-containing proteins

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However, no controlled human trial has compared oral versus injectable AOD-9604 at equivalent systemic doses

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