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It was frequently discussed on forums, research blogs, and experimental protocol discussions

When using hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, follow patients at frequent intervals and consider increasing the opioid dosage, if needed, to maintain adequate analgesia or if symptoms of opioid withdrawal occur [see PRECAUTIONS, Drug Interactions]

doi: 10.2147/IJN.S389260 [DOI] [PMC free article] [PubMed] [Google Scholar] 308.Kim MS, Lee E-J, Kim J-W, et al

Loss of function in the encoded transporters results in impaired biliary cholesterol efflux, clinically recognized as sitosterolemia

Finally, human tissue samples, such as those from adipose tissue, skeletal muscle, and pancreatic islets, obtained from diabetic patients or healthy volunteers, present a direct window into SLC7 transporter activity in human metabolism