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10.1038/s41586-023-06878-9 36 GaoQ.ZhouY.ChenY.HuW.JinW.ZhouC.et al (2025)

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[ 210 , 211 ] Knocking out BACH1 significantly inhibits cell proliferation in hDPSCs, causing cell cycle arrest, reducing alkaline phosphatase activity, decreasing calcium deposition, and downregulating mineralization markers' expression in a manner independent of HO1

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The NADH then is oxidized by a series of chemical reactions in the mitochondria (i.e., the mitochondrial electron transport system, or respiratory chain), eventually resulting in the transfer of electrons to molecular oxygen (O 2 ), which then binds protons (H + ) to generate water (H 2 O)