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Active compounds, such as astragaloside IV, attenuate diabetes-related activation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), NF-B, and extracellular signal-regulated kinases 1 and 2 (Erk1/2) signaling pathways, thereby decreasing podocyte apoptosis and albuminuria in preclinical models (135)

Kopetz S , Cutsem EV, Kuboki Y, Johnson B, Katakabe T, He M, Archuadze S, Shen L

Importantly, loss-of-function mutations of fumarase, an enzyme in TCA cycle, can make cancer cells more resistant to CDI ferroptosis, thus conferring tumorigenic advantage [277]

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