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However, combining multiple compounds that compete for the same receptors or cellular resources may require adjustment of dosing frequency for both agents

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[23] Additional tests of neuroanatomy and neurotransmitter levels were also performed on these rats, which were compared to both their non-treated and saline-treated counterparts

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Sometimes we need to also improve GI transit at the smooth muscle level (by utilizing the serotonin precursor 5-HTP for example.) As mentioned, hormones need to be normalized as well