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It inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase, and it has broad antimicrobial activity against aerobic and anaerobic gram-positive and gram-negative bacteria [93]

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Now, the unreactive carboxylic acid has been converted into a much more reactive acyl adenylate

Diagnosis of a thyroid storm is based on the following: A medical history is obtained from the patient, who may have been diagnosed as suffering from thyroid disease in the past and gives the history of a precipitating event

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After standard dehydration, samples were infiltrated and embedded in Spurr low-viscosity resin (Electron Microscopy Sciences) and polymerized at 60 C for 18 h