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GHK-Cu has been shown in cell culture to increase dermal papilla cell proliferation and protect these cells from programmed cell death (apoptosis), shifting the Bcl-2/Bax survival balance in favor of cell protection

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The peptide also delivers copper as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for proper collagen cross-linking and structural integrity

Tiller J, Bouwer C, Behnke K

Finally, cells were tested in flow cytometry (Becton Dickinson, FACS Verse, USA)

The data showed Nrf2 protein expression increased in asthmatic mice, although GSH-EE supplementation had no effect on altering Nrf2 mRNA levels and protein expression in our experiments
