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Two-day-old rats were subjected to an intraperitoneal injection of either DMF (0.35 mole/g body weight) in 10% ethanol/90% saline solution, or vehicle only

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(77) reported a decrease in the gene expression of MMP-2 and MMP-9 alongside an increase in TIMP1 expression in murine skin exposed to UVB radiation when 20 mg/kg areca nut PCs were orally administered to mice, indicating their ability to mitigate collagen degradation and slow photoaging effects on the skin through the inhibition of the MAPK signaling pathway