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STERILE INFLAMMATION AND APAP HEPATOTOXICITY The extensive cell necrosis after an APAP overdose leads to release of damage-associated molecular patterns (DAMPs) including mitochondrial DNA, nuclear DNA fragments, high-mobility group box 1 (HMGB1) protein, and many others108110 (Fig

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Notably, SAB treatment also enhanced the PRDX1 binding at DOK3 by Co-IP assay (Fig

Total DNA in feces was extracted according to the instructions of the DNA extraction kit (MN NucleoSpin 96 Soi, US), and the V3-V4 region of 16S rDNA was opened with primers with barcodes