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These complexes activate the complement system and mediate inflammatory damage, ultimately resulting in multisystem involvement affecting the skin, kidneys, joints, and other organs (140)

Macrocyclization can convey drug-like properties of larger molecules (Driggers et al., 2008

Similarly, expression of fur- regulated IgA1 protease ( hxuCBA, hbpA, hpe or sapA haem-acquisition systems had an impaired ability to invade type II pneumocytes (Rodrguez-Arce et al., 2019)

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