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[DOI] [PubMed] [Google Scholar] Corrales RM, Luo L, Chang EY, Pflugfelder SC

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Sodium valproate is commonly accepted in migraine prophylaxis, with reports on the reduction in the number of migraine attacks or days with migraine by about 50% in about half of migraine patients [102]

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In the key step, this intermediate is reduced by catalytic hydrogenation with a transfer of chirality to the carbon atom alpha to the amino group