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VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135,136]

Neurology 88, 20262035

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Moreover, it cannot be excluded that the activation status of immune cells may differ from that observed in natural bacterial inflammation, as the LPS injection is a research model lacking the dynamics of a bacterial infection

Jood S, Kapoor AC, Singh R

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