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The purified proteins were concentrated with 50-kDa Merck Millipore filters and solubilized with HEPES buffer (54.55 mM HEPES, 275 mM NaCl, 1.48 mM Na 2 HPO 4 )

18 The mitochondrial ubiquitin ligase MARCH5, a critical regulator of mitochondrial dynamics, mitophagy, and apoptosis, is demonstrated to protect endothelial function against hypoxia/ischemic injury via serine/threonine kinase AKT/eNOS (endothelial NO synthase) axis

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Additionally, these compounds stimulate -oxidation of fatty acids, promote lipolysis, and suppress lipogenesis, collectively improving lipid metabolism and reducing fat accumulation (498)

doi: 10.1021/acsami.1c06687

In addition, the library also contains 84,446 MS 2 spectra of all dipeptides, all tryptic tripeptides, and many bioactive peptides