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Abstract Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes significant morbidity and mortality, and is becoming an increasingly common health problem because of the increasing longevity and prevalence of predisposing factors such as sedentary lifestyle, obesity and nutritional habits

Contraindications: This preparation should not be used by individuals who are sensitive to cobalt or vitamin B12. Additionally, it contains benzyl alcohol and should not be used in newborns or individuals who are sensitive to benzyl alcohol

Most healthcare providers will look at the "benefit-to-risk" ratio

patients in both arms received folic acid, vitamin B 12, and dexamethasone [see Dosage and Administration (2.4)]

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[12] [13] Suspected adverse reactions should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)