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doi: 10.1016/j.cmet.2015.07.017

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Recombinant human IGF-1, given over 6 months at a dose FDA-approved for long-term treatment of growth failure in children with severe primary IGF-1 deficiency, reduced coronary artery atherosclerosis and promoted a stable plaque phenotype in a pig model of familial hypercholesterolemia (FH) (148)

Ibarra C, Vicencio JM, Estrada M et al (2013) Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors

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