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doi: 10.3390/ph17081081

Lipoxygenase/Leukotriene Pathway Activation of 5-lipoxygenase (LOX) in ( primarily expressed in leukocytes ) results in the conversion of arachidonic acid to leukotrienes that function as inflammatory mediators (Wikipedia) resulting in: bronchoconstriction increased secretion of mucus leukocyte chemotaxis histamine release This pathway has its greatest clinical relevance in the pathophysiology of asthma

Albrecht, P

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It has been found that estradiol benzoate, for example, causes a change in the expression of ECS components (CB 1 R, CB 2 R, FAAH) in the rat uterus, in an estrogen receptor-dependent way, indicating potential for hormonal regulation of the ECS in reproductive tissues (Maia et al., 2017)