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High mobility group box 1 protein (HMGB1), S100 proteins, lysophosphatidic acid (LPA), amyloid beta (A), and phosphatidylserine (PS) are capable of binding to receptors such as RAGE, thereby initiating a cascade of cellular signal transduction processes [29]

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Wittgenstein subsequently tested an aqueous solution of DHA on her own skin, which also turned brown
Table 2 Summary of emerging therapy for ED: peripherally acting agents 3

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