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10.1002/14651858.CD000543.pub5

Active site residues U46, K48, Q81, and W136 are highlighted and shown as sticks

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PD-1 negatively modulates proliferation, cytokine secretion, and survival of CD4 T-cells

However, administration of the ferroptosis inhibitor ferrostatin-1 has been shown to suppress lipid peroxidation, restore GSH levels, reduce iron accumulation, and markedly attenuate neuronal death (63), suggesting that targeting ferroptosis could provide therapeutic benefits in HD