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Some US formulations also use glycol-based carriers, which is a separate consideration for users who microneedle or have scalp sensitivity

However, its been found that oral B12 supplementation when taken in high doses can have similar protective effects

Current approaches include: Continuous Use Approach: Based on clinical trials that used continuous daily administration for 12-24 weeks without scheduled breaks

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Certain individuals are at a higher risk for B12 deficiencyincluding those following strict vegan or vegetarian diets, as well as patients with conditions that impair nutrient absorption, such as pernicious anemia, celiac disease, Crohns disease, or a history of gastrointestinal surgery