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Moreover, AMBRA1 synergistically interacts with the E3 ubiquitin ligase HUWE1 to recruit LC3B indirectly and induce mitophagy in response to mitochondrial depolarization [151]

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It is particularly common among older demographics, where skin becomes less effective at producing Vitamin D, or among people with darker complexions

Hepatology 65 , 12491266 (2017)