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Description
Minimal residual disease (MRD) after hyper-CVAD and Imatinib mesylate (STI571) for Philadelphia (PH) positive adult acute lymphoblastic leukemia (ALL)

Although it is an FDA-approved drug for the treatment of urea cycle disorders and has a well-known safety profile, only a few clinical trials have been conducted to investigate its potential for treating neurodegenerative diseases

Targeting c-Met and EpCAM: a way to overcome drug resistance It has been well established that aberrantly expressed EpCAM has a direct impact on the cell cycle, proliferation, and upregulation of the oncogenic transcription factors c-Myc and cyclin A/E [150]

Conversely, underexpression of Trx in white wheat seed has been tried

References Adler V, Yin Z, Fuchs SY, Benerza M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ and Ronai Z

However, the development of highly specific ferroptotic drugs with low cytotoxicity is key, as current drugs have the potential to induce other types of renal cell disease (162)
