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[188] constructed a macrophage-targetable delivery system using polyethylenimine (PEI) and poly (-amino amine) (PBAA) as siERN1 carriers (FA PEG R (Peptide: RKKRRQRRR) NPs (ss-PBAA-PEI)@siERN1) with a diameter of ~ 110.0 nm through self-assembly, which released endoplasmic reticulum nucleus signaling 1 gene (siERN1) under pH 5.5/GSH to modulate [Ca 2+ ]i levels (detected by flow cytometry and CLSM with fluo-4AM labeling) in LPS-stimulated RAW 264.7 cells by disturbing inositol 1,4,5-trisphosphate receptor 1/3 (IP3R1/3), thereby initiating M1-to-M2 polarization as demonstrated by WB, RT-qPCR to maintain immune homeostasis, demonstrating superior therapeutic efficacy in CIA and dextran sulfate sodium salt-induced IBD (Fig

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