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Why that matters: it's not one big effect it's many small, coordinated ones

[DOI] [PubMed] [Google Scholar] 43.Domingues M.J., Cao H., Heazlewood S.Y., Cao B., Nilsson S.K

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By converting phospholipid hydroperoxides into harmless alcoholic derivatives, GPX4 effectively inhibits membrane lipid peroxidation and suppresses ferroptotic cell death (118)

5.2 Precision medicine approaches The success of redox-based therapy will depend on precision stratification

Similarly, a mouse model study showed that a reduction in mitochondrial DNA polymerase g (POLG) is linked to higher levels of mutations and more apoptotic markers relative to the control group with intact POLG expression levels (Lee and Wei, 1997