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Deliver triglycerides from the liver to muscle and adipose tissue Converted into IDL and eventually LDL after triglyceride removal Important in maintaining energy supply during fasting Elevated VLDL levels are commonly associated with hypertriglyceridemia

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The explanation for this process is that cholesterol and PI(4)P are synthesised at two different locations, i.e., the endoplasmic reticulum for sterols and the trans-Golgi network and plasma membrane for PI(4)P, so the two lipids do not compete but rather can be exchanged

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March 6, 2018