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Thinking at first that thiamine had lost its biologic activity, when tested in animals the new compound was found to have a greater biologic activity than the original thiamine

The three forms of vitamin B12, cyanocobalamin, methylcobalamin, and adenosylcobalamin have been shown to have different conversion and absorption rates, with methylcobalamin (the naturally occurring form of B12) regarded as the most optimal for assisting in the methylation cycle

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This finding is consistent with the Australian study described above (24) that found cognitive performance was impaired in participants who had high RBC folate and serum vitamin B-12 within the low-normal range