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Innovative therapeutic approaches in non-alcoholic fatty liver disease: when knowing your patient is key

GPx4 also affects metabolic diseases, such as NAFLD (non-alcoholic fatty liver disease), where cGPx4 protein expression is down-regulated and induces the non-classical transcriptional variant iGPx4, which promotes ferroptosis by interacting with cGPx4 and converting it from an active monomer to an inactive oligomer, and OSA (obstructive sleep apnea), where macrophage-secreted IL6 promotes hepatocyte MARCH3 expression, mediates GPx4 ubiquitination degradation and exacerbates ferroptosis and lipid accumulation

This can lead to a more even, "glowing" appearance rather than a dramatic change in base skin color

This finding underscores the essential role of antioxidant defense mechanisms in facilitating bacterial adaptation to the intracellular milieu

The integration event itself may disrupt the functions of key genes in the host cell