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The Novel Dihydroorotate Dehydrogenase (DHODH) Inhibitor PTC299 Inhibit De Novo Pyrimidine Synthesis with Broad Anti-Leukemic Activity Against Acute Myeloid Leukemia

Rijken et al., 2011)
10.1513/pats.200512-125SF Proc Am Thorac Soc

In cisplatin-treated male mice, there were no differences in inner HC (IHC) loss or outer HC (OHC) loss in the apical, middle, and basal cochlear regions between WT and Gsta4 / mice (Supplementary Fig

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It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate
