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The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture) Angewandte Chemie

10.1016/j.ejphar.2004.03.061 [DOI] [PubMed] [Google Scholar] Johnson E

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Each isoform is encoded by a separate gene

They sit at the intersection of skin renewal, barrier support, visible firmness and cosmetic rejuvenation, which makes them especially interesting for people who want results without building an overly aggressive routine