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Certain genetic mutations, particularly those affecting the X chromosome, can be an underlying cause of premature ovarian insufficiency (also known as primary ovarian insufficiency), a condition in which menstrual cycles become irregular or cease and FSH levels are persistently high before the age of 40 years

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Yuan H, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] Hofmeister F

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