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MOTS-c regulates cell metabolism primarily through the AICAR (5-aminoimidazole-4-carboxamide ribonucleotide)-AMPK pathway, which controls glycolysis, mitochondrial activity, and fatty acid oxidation [12]

In oxaliplatin-treated mice, aluminum was accumulated in the dorsal root ganglia (DRG), and accumulated aluminum in DRG or other organs aggravated oxaliplatin-induced neuropathic pain

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The potential involvement of a dopaminergic mechanism in this process was inferred from the blocking action of pimozide, a dopamine antagonist, on the DSIP-induced GH increase

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The copper delivery aspect is particularly important because lysyl oxidase (the enzyme that cross-links collagen into strong fibers) is copper-dependent