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After they are secreted into the circulation, lipoprotein lipase (LPL) metabolizes VLDL to produce IDL, which is further metabolized by LPL and hepatic lipase to form cholesteryl ester-rich LDL

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[DOI] [PubMed] [Google Scholar] Steiber A., Kerner J., Hoppel C.L

Additionally, the synthesis of LDL receptors increases to allow increased cholesterol uptake for bile acid synthesis, and the overall effect is a reduction in plasma cholesterol

PubMed Minder EI, et al

according to Time , he "wears a gee-whiz expression, spouts homilies out of a lopsided mouth and lopes around uncertainly like a plowboy stepping through a field of cow dung