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ALC counteracts oxidative stress and senescence by up-regulating Heat-shock proteins, Nrf2 signalling, HO-1, and SOD and promotes the transcription of the Grm2 gene [158, 166, 167, 170, 185]

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6(2): 1617 Acknowledgements Experiments on the regulation of mGlu2 receptor expression by ALC were supported by the McDonnell Center for Molecular and Cellular Neurobiology and by the National Institutes of Health