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However, it has been proposed that GPER induces expression of ER36, a short isoform of the classical long isoform of ER, ER66 (23)

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Metabolis 57(10):13691374

Although many molecules can function as oxidants, in vivo reactive oxygen species (ROS) and reactive nitrogen species (RNS) are of relevance

When iron is deficient, these processes are reversed, with the end result being a match between the levels of iron and PP 9, the two substrates for the final enzyme of heme biosynthesis, namely, ferrochelatase [FECH], thus minimizing excesses of toxic substrates in erythroblasts

Ratziu V, Giral P, Jacqueminet S, et al