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However, because many people live undiagnosed for years with autoimmune conditions like celiac disease or Hashimoto's (and often both), it can often show up around the same time

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Cell 162: 540551 Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M, Liebman HM, Kwak EL, Clark JW, Ryan DP, Deshpande V, DiasSantagata D, Ellisen LW, Zhu AX, Iafrate AJ (2012) Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broadbased tumor genotyping

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In summary, mesoporous silica and hybrid nanocarriers represent one of the most mature inorganic platforms in nanomedicine, yet their clinical translation remains constrained by issues of reproducibility, biodegradation kinetics, and immunogenicity